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Dysfunction of glucose metabolism in the entire brain or specific cell types, including ischemic brain injury and neurodegenerative diseases, is closely related to neurological pathology (Zhang S
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Scalissi NM1
The second step in BH 4 synthesis, catalyzed by 6-pyruvoyltetrahydropterin synthase (PTPS), involves the Zn 2+ and Mg 2+ -dependent rearrangement of 7,8-dihydroneopterin triphosphate, with concommitant loss of the triphosphate, to 6-pyruvoyltetrahydropterin
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